hrp0097fc7.3 | Sex differentiation, gonads and gynaecology or sex endocrinology | ESPE2023

ROS scavengers may improve genital skin healing in boys with hypospadias

K Lucas-Herald Angela , Hussain Samra , McGinley Kirsty , O'Toole Stuart , Flett Martyn , Steven Mairi , Lee Boma , Basith Amjad S , Faisal Ahmed S

Introduction: Hypospadias is often associated with reduced testosterone synthesis or action. High rates of complications are reported with surgical repair of hypospadias, including wound dehiscence. Boys with hypospadias have previously been demonstrated to have increased reactive oxygen species (ROS) compared to healthy controls and there is a known link between male hypogonadism and oxidative stress. It is not clear what effect ROS has on wound healing in bo...